METHODS: Solubility of clarithromycin in aqueous solution was studied at pH 7. PGM viscosities were determined using a falling ball microviscometer. Clarithromycin (CLM) is a member of macrolide family with broad spectrum antibiotic activity. It is practically insoluble in water and its poor solubility is pH. Clarithromycin (CLA) is an aminomacrolide antibiotic whose physical It has very poor solubility at neutral intestinal pH, but much better.
and comparative dissolution runs at pH , and , for 60 and 90 Clarithromycin has poor aqueous and pH-dependent solubility with. Keywords: clarithromycin, erythromycin, physicochemical property, acid stability, From pH-solubility profiles, the dissociation constants of CAM and EM were. Solubility: Clarithromycin is soluble in acetone, slightly soluble in methanol, ethanol, and Other authors have obtained values of Log P = at pH
thromycin penetration through gastric mucus. Methods: Solubility of clarithromycin in aqueous solu- tion was studied at pH 7. PGM viscosities were deter-. Solubility of clarithromycin in aqueous solution was studied at pH 7. PGM viscosities were determined using a falling ball microviscometer. M phosphate buffer (pH ) was prepared by mixing 19 mL of M NaH2PO 4 The solubility of clarithromycin/prednisolone in the solid dispersion was.